A streamlined tool for eplet analysis of donor and recipient HLA (human leukocyte antigen) mismatch. Messy, low-resolution HLA typing data is cleaned, and imputed to high-resolution using the NMDP (National Marrow Donor Program) haplotype reference database <https://haplostats.org/haplostats>. High resolution data is analyzed for overall or single antigen eplet mismatch using a reference table (currently supporting 'HLAMatchMaker' <http://www.epitopes.net> versions 2 and 3). Data can enter or exit the workflow at different points depending on the user's aims and initial data quality.
Version: | 1.0.0 |
Depends: | R (≥ 4.1.0) |
Imports: | devtools, tidyverse, dplyr, reshape2, schoolmath, tibble, tidyselect, stringr, purrr, tidyr, utils, readr, janitor |
Suggests: | knitr, rmarkdown |
Published: | 2023-01-31 |
DOI: | 10.32614/CRAN.package.hlaR |
Author: | Joan Zhang [aut, cre], Aileen Johnson [aut], Christian P Larsen [cph, aut] |
Maintainer: | Joan Zhang <joan.zhang at emory.edu> |
BugReports: | https://github.com/LarsenLab/hlaR/issues |
License: | MIT + file LICENSE |
URL: | https://pubmed.ncbi.nlm.nih.gov/35101308/, https://emory-larsenlab.shinyapps.io/hlar_shiny/ |
NeedsCompilation: | no |
CRAN checks: | hlaR results |
Reference manual: | hlaR.pdf |
Vignettes: |
Imputation Eplet Mismatch |
Package source: | hlaR_1.0.0.tar.gz |
Windows binaries: | r-devel: hlaR_1.0.0.zip, r-release: hlaR_1.0.0.zip, r-oldrel: hlaR_1.0.0.zip |
macOS binaries: | r-release (arm64): hlaR_1.0.0.tgz, r-oldrel (arm64): hlaR_1.0.0.tgz, r-release (x86_64): hlaR_1.0.0.tgz, r-oldrel (x86_64): hlaR_1.0.0.tgz |
Old sources: | hlaR archive |
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