rpact
Confirmatory Adaptive Clinical Trial Design, Simulation, and
Analysis.
Functional Range
- Fixed sample design and designs with interim analysis stages
- Sample size and power calculation for
- means (continuous endpoint)
- rates (binary endpoint)
- survival trials with flexible recruitment and survival time
options
- count data
- Simulation tool for means, rates, survival data, and count data
- Assessment of adaptive sample size/event number recalculations based
on conditional power
- Assessment of treatment selection strategies in multi-arm
trials
- Adaptive analysis of means, rates, and survival data
- Adaptive designs and analysis for multi-arm trials
- Adaptive analysis and simulation tools for enrichment design testing
means, rates, and hazard ratios
- Automatic boundary recalculations during the trial for analysis with
alpha spending approach, including under- and over-running
Installation
Install the latest CRAN release via
install.packages("rpact")
Development version
To use a feature from the development version, you can install the
development version of rpact from GitHub.
# install.packages("pak")
pak::pak("rpact-com/rpact")
Documentation
The documentation is hosted at www.rpact.org
Vignettes
The vignettes are hosted at www.rpact.org/vignettes
The rpact user group
The rpact project has an active user group consisting of
decision-makers and users from the pharmaceutical industry and CROs, who
meet regularly and, e.g., discuss best practices.
We invite you to be part of the rpact user group: benefit
from know-how, shape open source development in Pharma!
Use on corporate computer
systems
Please contact us to
learn how to use rpact on FDA/GxP-compliant validated
corporate computer systems and how to get a copy of the formal
validation documentation that is customized and licensed for exclusive
use by your company, e.g., to fulfill regulatory requirements. The
validation documentation contains the personal access data for
performing the installation qualification with
testPackage().
www.rpact.com/contact
About
- rpact is a comprehensive validated R
package for clinical research which
- enables the design and analysis of confirmatory adaptive group
sequential designs
- is a powerful sample size calculator
- is a free of charge open-source software licensed under LGPL-3
- particularly, implements the methods described in the recent
monograph by Wassmer and Brannath
(2016)
For more information please visit www.rpact.org
- RPACT is a company which offers
- enterprise R/Shiny software development services
- technical support for the rpact package
- consultancy and user training for scientists using R
- validated software solutions and R package development for clinical
research
For more information please visit www.rpact.com