# Placental Epigenetic Clock to Estimate Aging by DNA Methylation

## Documentation for package ‘rplec’ version 0.1.3

- DESCRIPTION file.
- User guides, package vignettes and other documentation.

## Help Pages

aging | Residual DNA-methylation-based (DNAm) gestational age
beta_v_indices | Indices for random beta values
bmiq_norm_450k | Normalize DNA methylation values
download_beta_values_case | Access Beta values at individual CpG sites for case group
download_beta_values_control | Access Beta values at individual CpG sites for control group
ga | Gestational age for both case and control groups
ipla | Identify placental aging
phenotype | Phenotype for both case and control groups
plec | Estimate DNA-methylation-based gestational age
plec_int_coef | Intercept and coefficients of placental epigenetic clock
plec_scaler_mean | Mean values of the scalers of placental epigenetic clock
plec_scaler_scale | Scale values of the scalers of placental epigenetic clock
probe_info_450k | Probe info for 450K
qc | Perform quality control